The multi-center, double-blind, placebo-controlled phase III RAPID study achieved its primary endpoint of converting sinus rhythm within 30 minutes of the subject’s self-administering etripamil. With guidance from the FDA in July 2020, Milestone altered the size and design of the NODE-301 study, which was later renamed RAPID. However, RAPID is the second part of a study, the first part of which, NODE-301, failed to achieve its primary endpoint, as reported by Milestone Therapeutics in March 2020. The phase III RAPID study evaluated the safety and efficacy of etripamil in patients with PSVT, a type of abnormal heart rhythm or arrhythmia. The company is developing it as a rapid-onset nasal spray to treat paroxysmal supraventricular tachycardia (PSVT), atrial fibrillation and other cardiovascular indications.

Milestone’s shares have returned 1.5% in the year-to-date period against the industry’s decline of 25.9%:Įtripamil is a potent short-acting calcium channel blocker designed by Milestone. Since 2007, more than 76 million jobs have been lost and this jobs gap is set to widen further mainly due to a continuous decline in the labour force in developed countries and rising unemployment in emerging economies.Shares of Milestone Therapeutics ( MIST Quick Quote MIST - Free Report) fell 21.67% during market hours on Oct 17, after rising 41% in premarket, post the company’s announcement of top-line results from a late-stage study evaluating its lead candidate, etripamil. Around 197 million people were unemployed in the world in 2015, and the projections are for a further increase in global unemployment by more than 3 million people over the next two years. It also presents projections for the period 2015–17 for employment and unemployment.Ī key finding is that the expansion of the world economy has been too weak to close the significant employment and social gaps that have emerged since the beginning of the global crisis in 2008. The report covers all countries in the world and describes patterns in the main regions and sectors. The World Employment and Social Outlook: Trends 2016 provides a global overview of recent trends in employment, unemployment and labour force participation as well as different dimensions of job quality such as vulnerable employment and working poverty.

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